Rosacea treatment and triggers info is on the way.
Soolantra Cream combats inflammatory lesions of rosacea with a formulation designed for tolerability, utilizing Cetaphil® Moisturizing Cream as the basis for the vehicle.1
Soolantra Cream Mechanism of Action
The mechanism of action (MOA) has not been confirmed.
The active ingredient, ivermectin, is a well-known antiparasitic that has also been reported to have anti-inflammatory properties.2-4
Reported Activity of Ivermectin2-4*
- No direct data (not possible to culture Demodex)
- Few supporting publications
Published clinical case series
- Demodicidosis, blepharitis, skin diseases
- Decreases cellular and humoral immune responses
- Parent compound avermectin has been shown to significantly regulate TNF-α, IL-1β and IL-10 in lipopolysaccharide-induced inflammation in in vitro studies
⋆The MOA of Soolantra Cream in treating rosacea lesions has not been confirmed.
Interview With Dr. Linda Stein Gold, Soolantra Cream Clinical Investigator
- Data on file. Galderma Laboratories, L.P.
- Stankiewicz M, Cabaj W, Jonas WE, Moore LG, Millar K, Ng Chie W. Influence of ivermectin on cellular and humoral immune responses of lambs. Vet Immunol Immunopathol. 1995;44:347-358.
- Labro MT. Anti-inflammatory activity of macrolides: a new therapeutic potential? J Antimicrob Chemother. 1998;41(suppl B):37-46.
- Ci X, Li H, Yu Q, et al. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. Fundam Clin Pharmacol. 2009;23:449-455.
Soolantra Cream Application Instructions
Instruct Patients to:
- Apply Soolantra Cream to the affected areas of the face once a day. Use a pea-sized amount of Soolantra Cream for each area of the face (forehead, chin, nose, each cheek) that is affected. Spread as a thin layer across the entire face, avoiding the eyes and lips.
- Hands should be washed after applying Soolantra Cream.
- Cosmetics may be applied after Soolantra Cream has dried.
- Soolantra Cream is not for oral, ophthalmic, or intravaginal use.