Get Ready!

Rosacea treatment and triggers info is on the way.


Soolantra Cream combats inflammatory lesions of rosacea with a formulation designed for tolerability, utilizing Cetaphil® Moisturizing Cream as the basis for the vehicle.1

Soolantra Cream Mechanism of Action

The mechanism of action (MOA) has not been confirmed.

The active ingredient, ivermectin, is a well-known antiparasitic that has also been reported to have anti-inflammatory properties.2-4

Reported Activity of Ivermectin2-4*

  • Antivermicidal
  • Demodex:
    • No direct data (not possible to culture Demodex)
    • Few supporting publications
    • Published clinical case series
      • Demodicidosis, blepharitis, skin diseases
  • Decreases cellular and humoral immune responses
  • Parent compound avermectin has been shown to significantly regulate TNF-α, IL-1β and IL-10 in lipopolysaccharide-induced inflammation in in vitro studies

The MOA of Soolantra Cream in treating rosacea lesions has not been confirmed.

Interview With Dr. Linda Stein Gold, Soolantra Cream Clinical Investigator

  1. Data on file. Galderma Laboratories, L.P.
  2. Stankiewicz M, Cabaj W, Jonas WE, Moore LG, Millar K, Ng Chie W. Influence of ivermectin on cellular and humoral immune responses of lambs. Vet Immunol Immunopathol. 1995;44:347-358.
  3. Labro MT. Anti-inflammatory activity of macrolides: a new therapeutic potential? J Antimicrob Chemother. 1998;41(suppl B):37-46.
  4. Ci X, Li H, Yu Q, et al. Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway. Fundam Clin Pharmacol. 2009;23:449-455.

Soolantra Cream Application Instructions

Instruct Patients to:

  1. Apply Soolantra Cream to the affected areas of the face once a day. Use a pea-sized amount of Soolantra Cream for each area of the face (forehead, chin, nose, each cheek) that is affected. Spread as a thin layer across the entire face, avoiding the eyes and lips.
  2. Hands should be washed after applying Soolantra Cream.
  3. Cosmetics may be applied after Soolantra Cream has dried.
  4. Soolantra Cream is not for oral, ophthalmic, or intravaginal use.