Let's clear up the facts
Combination treatment has the potential to improve outcomes. For this study, we added Oracea® (doxycycline, USP) 40mg Capsules to Soolantra® (ivermectin) Cream, 1% to measure efficacy and ensure the treatment approach aims for 'clear'.1 Clear is defined as IGA score of 0 according to the IGA (Investigator Global Assessment) scale, which is commonly used by dermatologists.
Both molecules have independent and cooperative effects on the inflammatory pathways of rosacea.
Oracea® Capsules: Pivotal Study Information
The efficacy and safety of non antibiotic dose doxycycline (40-mg doxycycline monohydrate formulated as 30-mg immediate release and 10-mg delayed release beads) for the treatment of rosacea was evaluated in 537 subjects aged > 18 years in identically designed, phase 3 trials.
Oracea® Capsules are indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients.
IGA = Investigator's Global Assessment.
Oracea Capsules Significantly Reduced Inflammatory Lesions vs Placebo2,9
8Total inflammatory lesion count = papules + pulstules.
Oracea Capsules Pivotal Studies: Safety10
The most commonly reported adverse events (>2%) in patients treated with Oracea Capsules were nasopharyngitis, sinusitis, diarrhea, hypertension and aspartate aminotransferase increase.9